Lipopeptide 200mg (Topical)

Lipopeptide is a common name for Biopeptide EL, also known as palmitoyl hexapeptide-12. As the name suggests, this peptide is made of six amino acids and has a palmitic fatty acid addition. The inclusion of palmitic acid within the Lipopeptide structure is thought to enhance penetration to the deeper layers of various structures made of skin cells. The amino acids in the peptide are valine-glycine-valine-alanine-proline-glycine (VGVAPG), and the sequence is one of the most common found in naturally occurring proteins like elastin and its precursor, tropoelastin.

By mimicking fragments of elastin, the peptide is thought to interact with fibroblast cells and exert a potential impact on the production of vital proteins to the skin’s extracellular matrix (ECM). Fibroblasts are a subset of cells found in connective tissue, such as the one that provides support for skin cells. Fibroblasts can actively produce ECM proteins, and some of the most important proteins are considered to be collagen, elastin, and hyaluronic acid. According to scientific research, Lipopeptide may potentially enhance the creation and growth of collagen and hyaluronic acid within the ECM.^[1]

Specifications

Sequence: Pal-Val-Gly-Val-Ala-Pro-Gly-OH or Palmitoyl – Hexapeptide-12

Molecular Formula: C₃₈H₆₈N₆O₈

Molecular Weight: 736.98g/mol

Synonyms: Oligopeptide-34, Biopeptide EL

Lipopeptide Research

Lipopeptide has been suggested to act primarily to support endogenous collagen and hyaluronic acid synthesis.^[2] This may be mediated by interacting with fibroblast cell function and proliferation. Below, we detail the latest laboratory research on these and other theoretical concepts.